Candid Patient Reviews of
Dr. Eric Daiter

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How Can I help You?

Dr Eric Daiter has served Monmouth and Middlesex Counties of New Jersey as an infertility expert for the past 20 years. Dr. Daiter is happy to offer second opinions (at the office or over the telephone) or new patient appointments. It is easy, just call us at 908 226 0250 to set up an appointment (leave a message with your name and number if we are unable to get to the phone and someone will call you back).


"I always try to be available for my patients since I do understand the pain and frustration associated with fertility problems or endometriosis."


"I understand that the economy is very tough and insurance companies do not cover a lot of the services that might help you. I always try to minimize your out of pocket cost while encouraging the most successful and effective treatments available."

NJ Center for Fertility and Reproductive Medicine - Infertility Tutorials

ICSI (detailed)
IntraCytoplasmic sperm injection (ICSI) is the most recent development in the field of assisted fertilization. The first pregnancy from any of the assisted fertilization techniques was reported in 1988, and resulted from partial zona dissection (PZD) in which a small incision or tear was made in the shell (zona pellucida) of the egg to aid access for sperm. These defects in the zona pellucida of the eggs were associated with a high number of polyspermic embryos (eggs fertilized with more than one sperm, therefore abnormal and not viable). Also in 1988 the first pregnancy from subzonal insertion of sperm (SUZI) was reported. In the SUZI procedure several sperm are placed into the perivitteline space between the outer shell of the egg (zona pellucida) and the plasma membrane of the egg. It was not until 1992 that the initial pregnancies with ICSI were reported, yet since that time this technique has overwhelmed the field of assisted fertilization.

The history of ICSI is interesting and shows how long it takes for medical advances to decome clinically available even in the most successful of situations.

In 1976, researchers reported that the injection of whole spermatozoa into hamster eggs resulted in the transformation of the sperm's nucleus into the male pronucleus. This illustrated that whole mature sperm can be microsurgically injected into the cytoplasm of eggs and the genetic material within the chromosomes (DNA) will organize into the normal structure (the male pronucleus). This important discovery allowed for the development of ICSI in humans.

In 1988, researchers first reported the finding that microinjection of human spermatozoa into human oocytes resulted in pronuclear formation. This confirmation that a similar procedure with human material resulted in a similar outcome occurred some 13 years after the initial hamster finding.

In 1992 the first pregnancies following intracytoplasmic injection of single spermatozoon into an oocyte were reported.

In 1997, ICSI has about a 60-80% fertilization rate per egg with an overall "take home baby" rate that compare nicely to rates of standard IVF performed for couples without a male factor.

This success for ICSI is incredible since the only criterion required for the sperm is that they are alive. Live sperm can be most easily detected by their motility but even nonmotile live sperm or immature sperm from testicular biopsy has been used successfully with ICSI. This is because the sperm do not have to accomplish fertilization on their own, rather, they are placed directly into the egg's cytoplasm.

Related Topics: Sperm


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Eric Daiter, M.D. - Edison, NJ - E-Mail: - Phone: (908)226-0250

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